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VERAPAMIL safety information
Because rivaroxaban is a substrate of verapamil cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) , drug–drug interactions with concomitant drugs that may influence the functions of CYP3A4 Pharmaceutics 2019, 11, 133; doi:10 . 3390/pharmaceutics11030133 verapamil for plantar fibroma verapamil structure verapamil icd-9 code como atua o verapamil www . com/journal/pharmaceutics Pharmaceutics verapamil in pregnancy verapamil mylan l.p. 240 verapamil for vertigo verapamil bradycardia 2019, 11, 133 and P-gp should be considered .
For example, ketoconazole (400 mg, qd) significantly increased the systemic exposure of rivaroxaban , whereas rifampicin, a CYP3A4 inducer, resulted in a 50% reduction in verapamil the systemic exposure of rivaroxaban  .
Non-dihydropyridine calcium verapamil 8 verapamil 15 gel verapamil kaina verapamil vasodilation verapamil 75 mg verapamil channel blockers (non-DHPs), verapamil and diltiazem, are also well known to be CYP3A4/P-gp inhibitors [6,7] and have been frequently prescribed in patients with arterial fibrillation [4,5] .
Therefore, concomitant use of rivaroxaban with these non-DHPs might lead to an increase in systemic rivaroxaban exposure and anticoagulant verapamil effects .
However, when compared with rivaroxaban use alone, verapamil the adjusted incidence rate for major bleeding did not significantly increase when patients with non-valvular arterial fibrillation were treated with concurrent use of both drugs  .
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